Treatment with AMD3100 attenuates the microglial response and improves outcome after experimental stroke
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چکیده
منابع مشابه
Social interaction improves experimental stroke outcome.
BACKGROUND AND PURPOSE Social interaction can have a profound effect on health. The purpose of the present study was to determine whether affiliative social interactions before and after stroke improve ischemic outcomes as assessed through histological analysis and behavioral assays. METHODS Male and female C57BL/6 mice were housed individually or with an ovariectomized female. Behavioral ass...
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BACKGROUND AND PURPOSE Delayed treatment of patients with stroke with levodopa/benserazide contributes to enhanced functional recovery, but the mechanisms involved are poorly understood. The present study was designed to investigate if levodopa/benserazide treatment improves recovery of lost neurological function and contributes to tissue reorganization in the rat brain after stroke. METHODS ...
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INTRODUCTION In up to one third of patients with mild stroke suitable to receive systemic thrombolysis the treatment is not administered because the treating physicians estimate a good spontaneous recovery. However, it is not settled whether the fate of these patients is equivalent to those who are thrombolysed. METHODS We analyzed 203 consecutive patients (134 men and 69 women, mean age 69±1...
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Stroke-induced immunodepression is an independent risk factor for stroke-associated pneumonia (SAP). Granulocyte-macrophage colony stimulating factor (GM-CSF) has neuroprotective properties in experimental stroke and been demonstrated to reverse immunodepression in sepsis patients. However, whether GM-CSF restores immune function after stroke preventing SAP and improving outcome is unknown. Her...
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Cerebral infarct (stroke) often causes devastating and irreversible losses of function, in part because of the brain's limited capacity for anatomical reorganization. The purine nucleoside inosine has previously been shown to induce neurons to express a set of growth-associated proteins and to extend axons in culture and in vivo. We show here that in adult rats with unilateral cortical infarcts...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2015
ISSN: 1742-2094
DOI: 10.1186/s12974-014-0232-1